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The addition of β-ketoacids to 4-(trifluoromethyl)pyrimidin- 2(1Н)-ones with decarboxylation: an effective method for the synthesis of 4-(2-oxoalkyl)-6-(trifluoromethyl)-3,4-dihydropyrimidin-2-ones

Authors :
Volodymyr A. Sukach
Viktor M. Tkachuk
Mykhailo V. Vovk
Serhiy V. Mel’nikov
Source :
Chemistry of Heterocyclic Compounds. 53:1124-1127
Publication Year :
2017
Publisher :
Springer Science and Business Media LLC, 2017.

Abstract

β-Ketoacids reacted with 4-(trifluoromethyl)pyrimidin-2(1Н)-ones according to the mechanism of Michael addition–decarboxylation, forming 4-(2-oxoalkyl)-6-(trifluoromethyl)-3,4-dihydropyrimidin-2-ones.

Details

ISSN :
15738353 and 00093122
Volume :
53
Database :
OpenAIRE
Journal :
Chemistry of Heterocyclic Compounds
Accession number :
edsair.doi...........e33c82757c053ad727c9392802ccaaac