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A comprehensive systematic review of the effectiveness of Akkermansia muciniphila, a member of the gut microbiome, for the management of obesity and associated metabolic disorders
- Source :
- Archives of Physiology and Biochemistry. 129:741-751
- Publication Year :
- 2021
- Publisher :
- Informa UK Limited, 2021.
-
Abstract
- Aims and background: Obesity is recognised as a significant public health burden worldwide. Recently the cross-talk between gut microbiota and obesity has attracted much attention. To that end, Akkermansia muciniphila has been proposed as a promising microbe to manage obesity. In the present systematic review, we evaluated evidence on the effectiveness and mechanisms of action of Akkermansia muciniphila supplementation in the management of obesity. Methods: Electronic databases of MEDLINE, PubMed, Scopus, Web of Science, and Google Scholar were searched thought March 2020 to identify relevant published articles, and eligible articles were systematically reviewed. Results and conclusions: Fifteen studies were included in the present study. Findings from the present review, which included human and animal (rodent) models support the effectiveness of Akkermansia supplementation as a novel therapeutic approach for the management of obesity and metabolic complications associated with obesity. However, future clinical trials are warranted to verify these outcomes. © 2021 Informa UK Limited, trading as Taylor & Francis Group.
- Subjects :
- medicine.medical_specialty
biology
Physiology
business.industry
Public health
MEDLINE
030209 endocrinology & metabolism
Akkermansia
General Medicine
Gut flora
biology.organism_classification
Management of obesity
Clinical trial
03 medical and health sciences
Therapeutic approach
0302 clinical medicine
030220 oncology & carcinogenesis
Physiology (medical)
medicine
Intensive care medicine
business
Akkermansia muciniphila
Subjects
Details
- ISSN :
- 17444160 and 13813455
- Volume :
- 129
- Database :
- OpenAIRE
- Journal :
- Archives of Physiology and Biochemistry
- Accession number :
- edsair.doi...........e395a8b67927466ac22f6887fb257936