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Quinoline containing acetyl hydrazone: An easily accessible switch-on optical chemosensor for Zn2+
- Source :
- Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy. 188:324-331
- Publication Year :
- 2018
- Publisher :
- Elsevier BV, 2018.
-
Abstract
- A simple chemosensor, namely, N-((quinolin-8-yl)methylene)acetohydrazide (1) was synthesized and used as an off–on fluorescence sensor, which exhibits high selectivity toward Zn2 + in aqueous media. The probe has large Stokes shift of > 200 nm, and its detection limit for Zn2 + is 89.3 nM. The binding process was confirmed through UV–vis absorption analysis, fluorescence measurements, mass spectroscopy study, 1H NMR spectra and density functional theory calculation. The crystal structures of Zn2 +, Ni2 +, and Cu2 + complexes based on 1 were determined through X-ray crystallographic analysis. The fluorescent probe was then applied to monitor intracellular Zn2 + in HeLa cells.
- Subjects :
- Detection limit
chemistry.chemical_classification
010405 organic chemistry
Quinoline
Hydrazone
Crystal structure
010402 general chemistry
Photochemistry
01 natural sciences
Fluorescence
Atomic and Molecular Physics, and Optics
0104 chemical sciences
Analytical Chemistry
chemistry.chemical_compound
symbols.namesake
chemistry
Stokes shift
Proton NMR
symbols
Methylene
Instrumentation
Spectroscopy
Subjects
Details
- ISSN :
- 13861425
- Volume :
- 188
- Database :
- OpenAIRE
- Journal :
- Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy
- Accession number :
- edsair.doi...........e3e5ee9f11e8485fa69254b1f35df200