Back to Search Start Over

Synthesis and Pharmacological Properties of 1,3-Bis[(S)Phenylethyl]Imidazolidine-2-Thione

Authors :
Haroon Ur Rahid
Muhammad Naveed Umar
Mohammad Sadiq
Muhammad Ayaz
Mohammad Shoaib
Ismail Shah
Imran Khan
Ikram Ilahi
Sher Wali Khan
Sumaira Miskeen
Source :
Pharmaceutical Chemistry Journal. 50:382-387
Publication Year :
2016
Publisher :
Springer Science and Business Media LLC, 2016.

Abstract

Enantiomerically and diastereomerically pure thiourea derivative (compound I) has been synthesized in two steps starting from (S)-1-phenylethanamine and 1,2-dibromoethane. Compound I was screened for various biochemical parameters including blood glucose level, serum total cholesterol level, serum bilirubin and triglyceride levels, serum glutamate pyruvate transaminase (SGPT) and alkaline phosphatase (ALP) activity in New Zealand White (NZW) rabbits. Compound I was also screened for brine shrimp cytotoxicity, antileishmanial and antioxidant activity. Acute toxicity tests in NZW rabbits were performed and the results showed that compound I was safe up to 2 mg/mL/kg rabbit body weight. For the blood parameters, it was found that compound I caused slightly reduced blood glucose level, increased blood serum bilirubin, ALP and SGPT levels, and caused no changes in cholesterol and triglyceride levels. Thus, results show that compound I possesses good cytotoxic, poor antileishmanial activity, and no prominent antioxidant activity.

Details

ISSN :
15739031 and 0091150X
Volume :
50
Database :
OpenAIRE
Journal :
Pharmaceutical Chemistry Journal
Accession number :
edsair.doi...........e409fa26582d176e2ffbc8e04a20ba9d