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Synthesis and Pharmacological Properties of 1,3-Bis[(S)Phenylethyl]Imidazolidine-2-Thione
- Source :
- Pharmaceutical Chemistry Journal. 50:382-387
- Publication Year :
- 2016
- Publisher :
- Springer Science and Business Media LLC, 2016.
-
Abstract
- Enantiomerically and diastereomerically pure thiourea derivative (compound I) has been synthesized in two steps starting from (S)-1-phenylethanamine and 1,2-dibromoethane. Compound I was screened for various biochemical parameters including blood glucose level, serum total cholesterol level, serum bilirubin and triglyceride levels, serum glutamate pyruvate transaminase (SGPT) and alkaline phosphatase (ALP) activity in New Zealand White (NZW) rabbits. Compound I was also screened for brine shrimp cytotoxicity, antileishmanial and antioxidant activity. Acute toxicity tests in NZW rabbits were performed and the results showed that compound I was safe up to 2 mg/mL/kg rabbit body weight. For the blood parameters, it was found that compound I caused slightly reduced blood glucose level, increased blood serum bilirubin, ALP and SGPT levels, and caused no changes in cholesterol and triglyceride levels. Thus, results show that compound I possesses good cytotoxic, poor antileishmanial activity, and no prominent antioxidant activity.
- Subjects :
- Pharmacology
Antioxidant
Triglyceride
010405 organic chemistry
Cholesterol
Bilirubin
medicine.medical_treatment
010402 general chemistry
01 natural sciences
Acute toxicity
0104 chemical sciences
chemistry.chemical_compound
Blood serum
chemistry
Imidazolidine
Drug Discovery
medicine
Alkaline phosphatase
Subjects
Details
- ISSN :
- 15739031 and 0091150X
- Volume :
- 50
- Database :
- OpenAIRE
- Journal :
- Pharmaceutical Chemistry Journal
- Accession number :
- edsair.doi...........e409fa26582d176e2ffbc8e04a20ba9d