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Menopausal status affects the susceptibility of stored RBCs to mechanical stress
- Source :
- Vox Sanguinis. 100:418-421
- Publication Year :
- 2010
- Publisher :
- Wiley, 2010.
-
Abstract
- The mechanical fragility index (MFI) is an in vitro measure of sublethal injury to RBCs. In our previous experiments, we demonstrated that an increase in sublethal injury (increasing MFI) was a component of the RBC storage lesion, and that the MFI was significantly higher amongst the RBC units from male donors compared to pre-menopausal female donors during storage. It was hypothesized that hormonal or menstrual factors contributed to this difference. In this study, we found that RBC units donated by post-menopausal women demonstrated an MFI that was significantly higher than those donated by pre-menopausal women throughout storage.
Details
- ISSN :
- 00429007
- Volume :
- 100
- Database :
- OpenAIRE
- Journal :
- Vox Sanguinis
- Accession number :
- edsair.doi...........e45f5ca7e04f4673665a9f5a32d08ec4