An assessment of temporal variation in the low molecular weight phlorotannin profiles in four intertidal brown macroalgae

Phlorotannins are a group of highly bioactive marine polyphenols found exclusively in brown algae (Phaeophyceae) where they play an integral role in chemical defence. Owing to their high degree of reactivity, phlorotannins have attracted recent commercial interest with potential for application in areas such as pharma-, nutra- and cosmeceuticals. However, to date, little is known regarding their biosynthesis and the factors that drive their natural variability, particularly in relation to their chemical properties such as polymerisation and isomerisation - two factors which directly influence their degree of activity. Low molecular weight (LMW