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Neodymium-Promoted Highly Selective Carbon–Carbon Double Bond Formation of Ketones with Allyl Halides in the Presence of Diethyl Phosphite

Authors :
Dengbing Xie
Yang Bo
Yiqiong Wang
Songlin Zhang
Source :
Synthesis. 52:3446-3451
Publication Year :
2020
Publisher :
Georg Thieme Verlag KG, 2020.

Abstract

The carbon–carbon double bond formation via neodymium-mediated Barbier-type reaction of ketones and allyl halides in the presence of diethyl phosphite is reported for the first time. The reaction is highly α-regioselective and was conveniently carried out under mild conditions in a one-pot fashion. From a synthetic point of view, a series of conjugated alkenes were obtained in moderate to good yields in this one-pot reaction with feasible reaction conditions.

Details

ISSN :
1437210X and 00397881
Volume :
52
Database :
OpenAIRE
Journal :
Synthesis
Accession number :
edsair.doi...........e4b8775f89594aa6b70326572a31edc1