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Neodymium-Promoted Highly Selective Carbon–Carbon Double Bond Formation of Ketones with Allyl Halides in the Presence of Diethyl Phosphite
- Source :
- Synthesis. 52:3446-3451
- Publication Year :
- 2020
- Publisher :
- Georg Thieme Verlag KG, 2020.
-
Abstract
- The carbon–carbon double bond formation via neodymium-mediated Barbier-type reaction of ketones and allyl halides in the presence of diethyl phosphite is reported for the first time. The reaction is highly α-regioselective and was conveniently carried out under mild conditions in a one-pot fashion. From a synthetic point of view, a series of conjugated alkenes were obtained in moderate to good yields in this one-pot reaction with feasible reaction conditions.
- Subjects :
- chemistry.chemical_classification
Reaction conditions
Double bond
010405 organic chemistry
Chemistry
Organic Chemistry
Reinforced carbon–carbon
chemistry.chemical_element
Conjugated system
Allyl halides
010402 general chemistry
Highly selective
01 natural sciences
Neodymium
Catalysis
0104 chemical sciences
One pot reaction
Polymer chemistry
Subjects
Details
- ISSN :
- 1437210X and 00397881
- Volume :
- 52
- Database :
- OpenAIRE
- Journal :
- Synthesis
- Accession number :
- edsair.doi...........e4b8775f89594aa6b70326572a31edc1