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PHOX-Based Phosphite-Oxazoline Ligands for the Enantioselective Ir-Catalyzed Hydrogenation of Cyclic β-Enamides
- Source :
- ACS Catalysis. 6:5186-5190
- Publication Year :
- 2016
- Publisher :
- American Chemical Society (ACS), 2016.
-
Abstract
- Simple Ir-PHOX-based phosphite-oxazoline catalysts have been successfully applied in the asymmetric hydrogenation of cyclic β-enamides providing better enantioselectivities than previous effective Ru and Rh catalysts. This protocol allows the synthesis of 2-aminotetralines and 3-aminochromanes, key structural units found in many therapeutic agents and biologically active natural products, in high chemical yields and enantioselectivities (ee’s up to 99%). High enantioselectivities have also been achieved in the hydrogenation of cyclic α-enamides.
- Subjects :
- 010405 organic chemistry
Asymmetric hydrogenation
Enantioselective synthesis
Noyori asymmetric hydrogenation
chemistry.chemical_element
General Chemistry
Oxazoline
010402 general chemistry
01 natural sciences
Catalysis
0104 chemical sciences
chemistry.chemical_compound
chemistry
Organic chemistry
Iridium
Subjects
Details
- ISSN :
- 21555435
- Volume :
- 6
- Database :
- OpenAIRE
- Journal :
- ACS Catalysis
- Accession number :
- edsair.doi...........e4bc7c30aea78f452c4d0d93b71fcbc0