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5-Membered ring heterocyclic carboxylic acids as angiotensin II antagonists
- Source :
- Bioorganic & Medicinal Chemistry Letters. 4:169-172
- Publication Year :
- 1994
- Publisher :
- Elsevier BV, 1994.
-
Abstract
- A series of 5-membered ring heterocyclic analogs of A-81988 were synthesized in order to determine their activity as angiotensin II antagonists. The activity of these compounds in a rabbit aorta in vitro assay ranged from pA2 values of
- Subjects :
- chemistry.chemical_classification
Stereochemistry
Carboxylic acid
Organic Chemistry
Clinical Biochemistry
Triazole
Pharmaceutical Science
Biological activity
Pyrazole
Biochemistry
Angiotensin II
Chemical synthesis
chemistry.chemical_compound
chemistry
Heterocyclic compound
Drug Discovery
Molecular Medicine
Thiazole
Molecular Biology
Subjects
Details
- ISSN :
- 0960894X
- Volume :
- 4
- Database :
- OpenAIRE
- Journal :
- Bioorganic & Medicinal Chemistry Letters
- Accession number :
- edsair.doi...........e4fd5a7ff107cb9d0b4ae947f516295f