ChemInform Abstract: Evidence for Spontaneous Cycloaromatization of Nine-Membered Monocyclic Enediyne

Treatment of 2,2-dimethyl-6-nonene-4,8-diynal (2) with CeCl3/LiN(TMS)2 at −5∼25°C gave 2,2-dimethyl-1-indanol (3) in a moderate yield. In the present study, acyclic (Z)-enediyne aldehyde (2) was cyclized to afford a nine-membered monocyclic enediyne (7), which cycloaromatized spontaneously at room temperature.