Shape Abnormalities of the Caudate Nucleus Correlate with Poorer Gait and Balance: Results from a Subset of the LADIS Study

Authors :: Örndahl, Eva
Macfarlane, Matthew D.
Bäzner, Hansjörg
Garde, Ellen
Looi, Jeffrey C.L.
Waldemar, Gunhild
Styner, Martin
Velakoulis, Dennis
Crisby, Milita
Erkinjuntti, Timo
Spulber, Gabriela
Walterfang, Mark
Wallin, Anders
Wahlund, Lars-Olof
Hennerici, Michael G.
Blahak, Christian
Publisher :: The University of North Carolina at Chapel Hill University Libraries
Abstract: Functional deficits seen in several neurodegenerative disorders have been linked with dysfunction in fronto-striatal circuits and with associated shape alterations in striatal structures. The severity of visible white matter changes (WMC) on MRI has been found to correlate with poorer performance on measures of gait and balance. This study aimed to determine whether striatal volume and shape changes were correlated with gait dysfunction.

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