Ozone Therapy Ameliorates Nervous System Disorders and Oxidative Stress in Patients During Ethanol Withdrawal—A Pilot Study

Chronic oxidative stress and acetaldehyde accumulation are associated with brain damage during Ethanol Withdrawal (EW). Ozone therapy is a regulator of cellular redox balance and it controls important functions of nervous system during EW at experimental level. The aim of this work was to develop a pilot study in order to evaluate the ozone´s effects on EW signs and oxidative stress in 10 patients “Before” and “After” ozone treatments. Ozone improved 70% of the signs from Clinical Institute Withdrawal Scale (CIWA-Ar), mainly those associated to Central Nervous System (CNS). Ozone´s efficacy was observed in patients that required pharmacological treatment. Reduction of CIWA-Ar scores and the oxidative stress (p < 0.05) was demonstrated. In summary, ozone improved CNS functions and reduced oxidative stress in patients during EW. These results were according to experimental findings and suggest ozone´s regulator effects on important neurotransmitters of the CNS.