Inflammatory cytokines and immune system response to weight reduction in obese patients with type 2 diabetes mellitus

Introduction:Systemic inflammation and activated immune system response are common features in obese patients with non-insulin dependent diabetes mellitus (NIDDM) as obesity-induced NIDDM represents a burden for healthcare systems worldwide. However, there is a strong association between BMI and the human immune system and systemic inflammation among obese patients with NIDDM.Material and Methods:Eighty obese patients with NIDDM participated in this study, their age ranged from 41-52 years and their BMI ranged from 31-36 kg/m2. All Subjects were included in two groups: The first group received life style modification in the form of treadmill aerobic exercises in addition to diet control where, the second group received no therapeutic intervention. Parameters of CD4 and CD8 cells count were quantified, IL-6, TNF-α, leptin and body mass index (BMI) were measured before and after 3 months at the end of the study.Results:The mean values of CD4 and CD8 cells count were significantly increased, where mean values of TNF-α, IL-6, IL-8 and body mass index (BMI) were significantly decreased in group (A). While group (B) showed non-significant changes in these parameters. Also; there were significant differences between mean levels of the investigated parameters in group (A) and group (B) at the end of the study.Conclusions:Within the limit of this study, life style modification modulates systemic inflammation and immunological parameters among obese patients with NIDDM.Objecttive:This study aimed to examine effects of weight reducing program on selected immune and systemic inflammation parameters among obese patients with NIDDM.