Single Molecule Imaging Reveals Dysferlin-Mediated Recruitment of Phosphatidylserine in Cell Membrane Repair

Dysferlin (Dysf) has been implicated as a key protein for membrane repair in muscle cells, although its precise biological function is still unknown. Dysf is a transmembrane protein, and its rapid recruitment of Dysf to membrane lesions has been observed; direct observation of Dysf transport has so far remained elusive [1]. Moreover, interaction of Dysf with various other proteins has been investigated for many years to understand its role in cell membrane repair; however, studies addressing the role of phospholipids, the main components of the plasma membrane, are still scarce.