Quantitative aspects in the determination of polychlorinated dibenzo-p-dioxins by high-resolution gas chromatography mass—spectrometry

Polychlorinated dibenzo-p-dioxins (PCDDS) are a group of compounds consisting of 75 isomers which are difficult to quantitate because of the lack of sufficient reference standards. A method of quantitation is developed which uses relative response factors for each isomeric group. Variations in gas chromatographic—mass spectrometric parameters do not bias the quantitation method for PCDDS. Testing the method using an environmental sample gives consistent data that can be used to study PCDD content in a number of samples.