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Improved Nitromethane-Hyamine Method for the Chemical Determination of Nitrofurantoin in Whole Blood
- Source :
- Clinical Chemistry. 16:820-823
- Publication Year :
- 1970
- Publisher :
- Oxford University Press (OUP), 1970.
-
Abstract
- The nitromethane-Hyamine method for assay of nitrofurantoin in whole blood has been improved: smaller volumes of blood (0.8 ml) are required, the sensitivity is greater (0.2 pg/mI), and the solution to be read is more stable than in the original method. The analysis detects 70 to 72% of 1 to 4 Ag of nitrofurantoin added per milliliter of whole blood. Blood concen-trations after the usual therapeutic peroral dose (100 mg) of nitrofurantoin are reported.
Details
- ISSN :
- 15308561 and 00099147
- Volume :
- 16
- Database :
- OpenAIRE
- Journal :
- Clinical Chemistry
- Accession number :
- edsair.doi...........e6a652863c9f5467ee44c79be6d0036b