Production of Tetrahydrocurcumin From Curcumin by Cultured Plant Cells and Inhibitory Effects of Curcuminoids on NF-κB Activity

Authors :: Manami Inoue
Yuya Fujitaka
Masayoshi Yanagi
Kei Shimoda
Hatsuyuki Hamada
Naoji Kubota
Hiroki Hamada
Tatsuya Onishi
Source :: Natural Product Communications. 14:1934578X1987892
Publication Year :: 2019
Publisher :: SAGE Publications, 2019.
Abstract: Biotransformation of curcumin was investigated using cultured plant cells of Morus sp. Cultured Morus cells converted curcumin into dihydrocurcumin and tetrahydrocurcumin. The activity of nuclear factor-κB was inhibited by curcumin and tetrahydrocurcumin.

Subjects :: Pharmacology
chemistry.chemical_compound
Complementary and alternative medicine
Biotransformation
chemistry
Drug Discovery
Curcumin
NF-κB
Plant Science
General Medicine
Plant cell
Inhibitory postsynaptic potential

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