THE F(ab???)2 FRAGMENT OF AN ANTI-ICAM-1 MONOCLONAL ANTIBODY ATTENUATES LIVER INJURY AFTER ORTHOTOPIC LIVER TRANSPLANTATION1

Long-term storage of liver grafts results in increased adhesion of leukocytes onto the sinusoidal walls. This eventually leads to posttransplant graft damage through disturbances of hepatic microcirculation. Intracellular adhesion molecule-1 (ICAM-1) is known to be involved in attachment of leukocyt