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Diversity and intratumoral heterogeneity in human gallbladder cancer progression revealed by single-cell RNA sequencing
- Publication Year :
- 2021
- Publisher :
- CNGB, 2021.
-
Abstract
- Gallbladder cancer (GC) is a malignant disease characterized with highly cellular heterogeneity and poor prognosis . Determine the intratumoral heterogeneity and tumor microenvironment (TME) can provide novel therapeutic strategies for GC. We performed the single-cell RNA sequencing (scRNA-seq) analysis on the cells dissociated from the primary, lymph node metastatic and the adjacent normal tissues of 5 GC patients. The transcriptomic atlas and the ligand-receptor based intercellular communication network between the cells were elucidated.
- Subjects :
- Multiisolate
Transcriptome or Gene expression
Raw sequence reads
Medical
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi...........e826a88be370fab35ae9a75d74f127bc
- Full Text :
- https://doi.org/10.26036/cnp0001599