ChemInform Abstract: Potent and Selective 5-LO Inhibitor Bearing Benzothiophene Pharmacophore: Discovery of MK-5286

Authors :: Anne Chateauneuf
Claudio Sturino
Lianhai Li
Zhaoyin Wang
Marc Ouellet
Carl Berthelette
Source :: ChemInform. 42
Publication Year :: 2011
Publisher :: Wiley, 2011.
Abstract: The synthesized substituted title benzothiophene (I) is able to serve as a novel scaffold of 5-lipoxygenase (5-LO) inhibitors and is selected to advance into pre-clinical development.

Subjects :: chemistry.chemical_compound
chemistry
Triazole derivatives
Benzothiophene
General Medicine
Pharmacophore
Combinatorial chemistry

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