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Role of leukotriene B4 in accelerated hyperlipidaemic renal injury
- Source :
- Nephrology. 16:304-309
- Publication Year :
- 2011
- Publisher :
- Wiley, 2011.
-
Abstract
- Aim: Glomerular infiltration of macrophages is a characteristic alteration of renal pathology in hyperlipidaemic renal injury. Leukotriene B4 (LTB4) is a bioactive eicosanoid and macrophage and has two key enzymes for LTB4 synthesis, 5-lipoxygenase and leukotriene A4 (LTA4) hydrolase. The purpose of this study was to evaluate the role of LTB4 in accelerated hyperlipidaemic renal injury. Methods: To induce accelerated hyperlipidaemic renal injury, 8 week old male spontaneously hypercholesterolaemic (SHC) rats were fed with a high cholesterol diet for 6 weeks. LTA4 hydrolase activities in the kidney and urine LTB4 levels were examined. The effects of LTB4 antagonist (ONO-4057) were also evaluated. Results: Urinary protein and LTB4 excretion was increased by a high cholesterol diet for 6 weeks. The scores of glomerular foam cell accumulation and sclerosis, numbers of infiltrated macrophages in glomeruli and interstitial area, LTA4 hydrolase activity in renal cortex were higher in the high cholesterol diet group than the normal diet group. LTB4 antagonist treatment reduced urinary protein and LTA4 activity and attenuated renal pathological changes. Conclusion: These results suggest that LTB4 directly contributes to accelerated hyperlipidaemic renal injury and the therapeutic potential of LTB4 antagonist for renal damage induced by hyperlipidaemia.
- Subjects :
- medicine.medical_specialty
Kidney
Normal diet
Leukotriene B4
business.industry
Renal cortex
Leukotriene A4
hemic and immune systems
General Medicine
respiratory system
urologic and male genital diseases
Leukotriene-A4 hydrolase
chemistry.chemical_compound
Endocrinology
medicine.anatomical_structure
chemistry
Renal pathology
Nephrology
Internal medicine
medicine
lipids (amino acids, peptides, and proteins)
business
Foam cell
Subjects
Details
- ISSN :
- 13205358
- Volume :
- 16
- Database :
- OpenAIRE
- Journal :
- Nephrology
- Accession number :
- edsair.doi...........e883c1888fb0bb7b3367849db06c8815
- Full Text :
- https://doi.org/10.1111/j.1440-1797.2010.01387.x