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Sub-50 nm core–shell nanoparticles with the pH-responsive squeezing release effect for targeting therapy of hepatocellular carcinoma

Authors :
Jian-Bo Qu
Huan-Jie Che
Bo Gao
Gang-Feng Li
Xue-Fei Zhang
Yi-Bo Zhang
Xiaojuan Wang
Source :
Journal of Materials Chemistry B. 11:4308-4317
Publication Year :
2023
Publisher :
Royal Society of Chemistry (RSC), 2023.

Abstract

The sub-50 nm pH-responsive nanoparticles have cross-linked acidic cores and galactosylated shells, which endow them with high targeting efficacy to hepatoma cells, high drug loading efficiency at pH 7.4, and rapid squeezable drug release at pH 5.0.

Details

ISSN :
20507518 and 2050750X
Volume :
11
Database :
OpenAIRE
Journal :
Journal of Materials Chemistry B
Accession number :
edsair.doi...........e8fda47458c4f075e3ba06f6a3acd981