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Socioepidemiology of Injection Drug Users in Miami and HIV-1B Envelope (V1–V5) Genetic Diversity: A Preliminary Study

Authors :
Paul Shapshak
J. Bryan Page
Brian T. Foley
Clyde B. McCoy
S. Balaji
David M. Segal
Source :
Global Virology II-HIV and NeuroAIDS ISBN: 9781493972883
Publication Year :
2017
Publisher :
Springer New York, 2017.

Abstract

Injection drug use is a major risk behavior associated with transmission of HIV-1B. Yet, despite its importance there have not been many detailed studies characterizing the transmission of HIV-1B in well-defined injection drug use networks. This preliminary study characterized people who were closely associated and injected drugs together under private circumstances compared to those who injected drugs in a context of public risk locales with many injectors in attendance. In this study, we examined networks of HIV-1B seropositive injection drug users (IDUs). We wished to ascertain whether socioepidemiological connections and relationships (including IDU and sexual) among individuals who inject drugs would be reflected in the molecular relatedness and clustering of their HIV-1B nucleotide and protein sequences – specifically hypervariable domains (V1–V5) of the HIV-1B envelope (env) gene. We wished to learn if there was a link between subject socioepidemiology and viral sequence diversity, phylogenetic relationships, signatures, thermodynamics, and glycosylation patterns. This chapter addresses whether in risk locales where many people inject together, there are variations in probability of relatedness of HIV-1B env sequences. In addition, it is pointed out that IDU behaviors are associated with psychiatric morbidities.

Details

ISBN :
978-1-4939-7288-3
ISBNs :
9781493972883
Database :
OpenAIRE
Journal :
Global Virology II-HIV and NeuroAIDS ISBN: 9781493972883
Accession number :
edsair.doi...........e90b1c2170d6b755ae1b5d5bcff3ce9e
Full Text :
https://doi.org/10.1007/978-1-4939-7290-6_15