Effect of sulfonation on the photosensitizing efficiency of aluminum phthalocyanine and meso-tetraphenylporphine in photodynamic therapy of cancer

The effect of sulfonations on the PDT efficiency of aluminum phthalocyanines and meso- tetraphenylporphines was studied in the CaD2 mouse mammary carcinoma. The PDT efficiencies were found to decrease in the following order: AlPCS2 > AlPCS4 > Photofrin > TPPS2a > AlPCS1 > TPPS4 > TPPS2o > TPPS1. Apparently, the degree of sulfonations of both families of dyes strongly affects the photobiological properties. It was found to be of great importance whether the sulfonate groups were located adjacently or opposite positions on the molecules.© (1994) COPYRIGHT SPIE--The International Society for Optical Engineering. Downloading of the abstract is permitted for personal use only.