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Mononucleosis infecciosa en pacientes con enfermedad inflamatoria intestinal en tratamiento con azatioprina

Authors :
José Luis Cabriada
Juan Antonio Arévalo
Míriam Mañosa
Miquel A. Gassull
Silvia Carrión
Ana Bargalló
Eduard Cabré
Eugeni Domènech
Source :
Gastroenterología y Hepatología. 31:289-292
Publication Year :
2008
Publisher :
Elsevier BV, 2008.

Abstract

The use of immunomodulators for the treatment of inflammatory bowel disease is increasing. One of the most common adverse effects associated with this kind of drugs are infectious complications. In recent years, special attention has been paid to certain latent infections which, in patients under immunomodulatory therapy, can be reactivated and prove lethal. Consequently, preventive actions have been adopted, such as screening for hepatitis B virus and tuberculosis infection before starting these treatments. Primary infection with the Epstein-Barr herpesvirus is usually asymptomatic. However, this virus can have an aggressive course and even lead to the development of lymphoma. We report two cases of atypical infectious mononucleosis in patients with inflammatory bowel disease under azathioprine therapy and review the available evidence on the most appropriate therapeutic approach in this subset of patients.

Details

ISSN :
02105705
Volume :
31
Database :
OpenAIRE
Journal :
Gastroenterología y Hepatología
Accession number :
edsair.doi...........eafd1d94f2dcbbf954fdbc134f3f6881
Full Text :
https://doi.org/10.1157/13119881