Biological Role of TRPC1 in Myogenesis, Regeneration, and Disease

The transient receptor potential canonical (TRPC) family consists of seven isoforms that have been proposed as molecular components essential for nonselective calcium (Ca2+) entry. TRPC1 proteins are expressed in the sarcolemma of skeletal muscles, and TRPC1 is important and necessary for stretch-activated and store-operated channels for Ca2+ entry. Studies have established the essential role of TRPC1 in maintaining Ca2+ homeostasis, regulating myoblast migration and differentiation, regenerating muscle, and contributing to the pathogenesis of muscular dystrophy. This chapter summarizes the evidence for the regulation of TRPC1 to fulfill specific physiological functions in skeletal muscles.