Overview of the Metastatic Cascade

Metastasis is one of the major problems if not the major problem in the diagnosis, staging and treatment of cancer. Although over the last few years, there have been major advances in our understanding of cancer, conceptual advances have often led to the recognition of many problems, where previously only comparatively few were recognized. This is particularly true for metastasis, where we are currently at the stage of recognizing at least some of the basic problems, and hopefully can begin to arrive at some of their solutions.