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Positive association between plasma levels of oxidized low-density lipoprotein and myeloperoxidase after hemodialysis in patients with diabetic end-stage renal disease
- Source :
- Hemodialysis International. 17:557-567
- Publication Year :
- 2013
- Publisher :
- Wiley, 2013.
-
Abstract
- End-stage renal disease (ESRD) patients undergoing hemodialysis (HD) have a high prevalence of cardiovascular events. Low-density lipoprotein (LDL) in dialysis patients has been shown to be susceptible to in vitro peroxidation; therefore, oxidized-LDL (ox-LDL) could be generated in these patients. Moreover, myeloperoxidase (MPO) released from activated neutrophils may play a role in the induction of LDL oxidation. The purpose of this study was to investigate the relationship between plasma ox-LDL levels, plasma MPO levels, and serum high-sensitivity C-reactive protein (hs-CRP) levels during initial HD in patients with diabetic ESRD. Patients (n=28) had serial venous blood samples drawn before and after HD at the initial, second, and third sessions. Plasma ox-LDL levels were measured using a specific monoclonal antibody (DLH3), and plasma MPO levels were measured using an enzyme-linked immunosorbent assay kit. Plasma ox-LDL levels and MPO levels after a single HD session increased significantly (ox-LDL, P
- Subjects :
- medicine.medical_specialty
biology
business.industry
medicine.medical_treatment
Inflammation
Hematology
Venous blood
medicine.disease_cause
End stage renal disease
Endocrinology
Nephrology
Internal medicine
Myeloperoxidase
medicine
biology.protein
In patient
Hemodialysis
medicine.symptom
business
Oxidative stress
Lipoprotein
Subjects
Details
- ISSN :
- 14927535
- Volume :
- 17
- Database :
- OpenAIRE
- Journal :
- Hemodialysis International
- Accession number :
- edsair.doi...........ed205215da4571e8cd80e217bc0fffcc