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Spielt VEGF bei den zyklischen Zervixveränderungen eine Rolle?
- Source :
- Geburtshilfe und Frauenheilkunde. 61:671-675
- Publication Year :
- 2001
- Publisher :
- Georg Thieme Verlag KG, 2001.
-
Abstract
- Objective: Around the time of ovulation the cervix opens and the cervical mucus liquefies. Vascular endothelial growth factor (VEGF), a potent inductor of vascular permeability, may play a role in these changes. We examined VEGF in cervical tissue specimens and cervical mucus at different stages of the menstrual cycle. Methods: Samples of tissue and mucus from the uterine cervix were obtained from specimens from 20 premenopausal patients undergoing hysterectomy. Eight uteri were removed during the follicular phase (day 1-8), five in the periovulatory phase (day 12 - 16), and seven in the secretory phase (day 17-28). Paraffin-embedded slides were stained with a VEGF antibody covering the splicing variants 165,189 and 121. Cervical mucus was examined for VEGF 165 with an enzyme-linked immunoassay. Data were analyzed with the Wilcoxon two-sample test. Results: Uteri in the early proliferative phase showed distinct VEGF staining of the basal epithelium of the cervix. During the late follicular and periovulatory phases, staining in the apical epithelium and cervical stroma increased and the VEGF concentration in the cervical mucus was highest (97 pg/mg total protein). After ovulation VEGF in the epithelium fell sharply, to then reappear in the mid and late secretory phase. Conclusion: VEGF increases in the cervical stroma around the time of ovulation and may play a role in the liquefaction of the cervical mucus and tissue edema. These changes are likely involved with the opening of the cervix at near the time of ovulation.
- Subjects :
- medicine.medical_specialty
media_common.quotation_subject
Obstetrics and Gynecology
Vascular permeability
Luteal phase
Biology
Mucus
Epithelium
Andrology
Vascular endothelial growth factor
chemistry.chemical_compound
Endocrinology
medicine.anatomical_structure
chemistry
Internal medicine
Maternity and Midwifery
Follicular phase
medicine
Ovulation
Cervix
media_common
Subjects
Details
- ISSN :
- 14388804 and 00165751
- Volume :
- 61
- Database :
- OpenAIRE
- Journal :
- Geburtshilfe und Frauenheilkunde
- Accession number :
- edsair.doi...........edae18b289bc00044a2a0cadd190b726