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Short-Term Intake of Hesperetin-7-O-Glucoside Affects Fecal Microbiota and Host Metabolic Homeostasis in Mice

Authors :
Yangyang Guo
Zunji Shi
Jinlin Zhou
Xuehang Zhu
Limin Zhang
Chuan Chen
Yuchen Song
Hehua Lei
Gui Chen
Yu-Jing Lu
Fang Wu
Zheng Cao
Manyuan Dong
Peihong Yuan
Caixiang Liu
Source :
Journal of Agricultural and Food Chemistry. 69:1478-1486
Publication Year :
2020
Publisher :
American Chemical Society (ACS), 2020.

Abstract

Hesperetin-7-O-glucoside (Hes-7-G) is a typical flavonoid monoglucoside isolated from Citri Reticulatae Pericarpium (CRP), which is commonly used as a food adjuvant and exhibits potential biological activities. To explore the interaction between Hes-7-G ingestion and microbiome and host metabolism, here, 16S rRNA gene sequencing was first used to analyze the alteration of fecal microbiome in mice after Hes-7-G intake. Metabolic homeostasis in mice was subsequently investigated using untargeted 1H NMR-based metabolomics and targeted metabolite profiling. We found that dietary Hes-7-G significantly regulated fecal microbiota and its derived metabolites, including short-chain fatty acids (SCFAs) and tryptophan metabolites (indole and its derivatives), in feces of mice. Regulation of microbiota was further confirmed by the significantly changed urinary hippurate and trimethylamine N-oxide (TMAO), co-metabolites of the microbe and host. We also found that dietary Hes-7-G modulated the host tricarboxylic acid cycle (TCA) involved in energy metabolism. These findings suggested that Hes-7-G exhibits potential beneficial effects for human health.

Details

ISSN :
15205118 and 00218561
Volume :
69
Database :
OpenAIRE
Journal :
Journal of Agricultural and Food Chemistry
Accession number :
edsair.doi...........ee68308161c1502cd3e80dd884a4ab97