Linkage ofaconitase-1 andmajor urinary protein-1 loci in male rats

A new major urinary protein alleleMup-lc with “null” activity was detected in males of the COP strain. The (BN X COP)F1 X COP backcross had significant segregation distortion of theMup-lc andAco-1 alleles that indicated a linkage between the genes, at a map distance of 13 ± 4 cM. The loci reside on the linkage group II of the rat with theb locus. According to our data and the results published previously, the map distance and the orientation of genes isb - 8 ± 4 -Mup-1 - 13 ±4-Aco-1. These genes form a syntenic group in both the mouse and the rat.