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Let-7c inhibits migration and epithelial-mesenchymal transition in head and neck squamous cell carcinoma by targeting IGF1R and HMGA2
- Source :
- Oncotarget. 9:8927-8940
- Publication Year :
- 2018
- Publisher :
- Impact Journals, LLC, 2018.
-
Abstract
- To elucidate the molecular mechanisms underlying the progression of head and neck squamous cell carcinoma (HNSCC), we investigated the function of let-7c as a tumor suppressor. Let-7c expression was significantly down-regulated in HNSCC tumor tissues and cell lines. In vitro and in vivo studies revealed that let-7c negatively regulated HNSCC proliferation, migration and epithelial-mesenchymal transition (EMT). To explore the underlying mechanisms that affect these molecular events achieved by let-7c, we predicted its target genes. We performed luciferase assay and confirmed that insulin-like growth factor 1 receptor (IGF1R) and high mobility group AT-hook 2 (HMGA2) were the direct targets of let-7c. Knocking down of IGF1R and HMGA2 inhibited HNSCC progression, including proliferation, migration and EMT in HNSCC cells. Re-expression of these genes overcame let-7c-mediated inhibition. Taken together, our finding suggests that let-7c inhibits HNSCC progression by targeting IGF1R and HMGA2 and might be a novel target for HNSCC treatment.
- Subjects :
- 0301 basic medicine
Growth factor
medicine.medical_treatment
Biology
medicine.disease
Head and neck squamous-cell carcinoma
law.invention
stomatognathic diseases
03 medical and health sciences
030104 developmental biology
0302 clinical medicine
HMGA2
stomatognathic system
Oncology
Cell culture
law
030220 oncology & carcinogenesis
otorhinolaryngologic diseases
biology.protein
medicine
Cancer research
Suppressor
Epithelial–mesenchymal transition
Receptor
Insulin-like growth factor 1 receptor
Subjects
Details
- ISSN :
- 19492553
- Volume :
- 9
- Database :
- OpenAIRE
- Journal :
- Oncotarget
- Accession number :
- edsair.doi...........ef3ed39f757350cfc2ee9cd94cf4fa79