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A Biocompatible, Biodegradable, and Functionalizable Copolyester and Its Application in Water-Responsive Shape Memory Scaffold
- Source :
- ACS Biomaterials Science & Engineering. 5:1668-1676
- Publication Year :
- 2019
- Publisher :
- American Chemical Society (ACS), 2019.
-
Abstract
- Shape memory polymers are of great interest for biomedical applications. However, most stimuli used to trigger shape memory processes, including heat, light, electricity, magnetism, and pH are inconvenient and maybe harmful to the body. Here, we designed and fabricated a new shape memory porous scaffold using biocompatible and readily available water as the trigger. This scaffold was based on poly(fumaricacid-co-1,7-octadiene diepoxide-co-terephthalic acid) (PFOT) synthesized via epoxide ring-opening polymerization in one step. The PFOT scaffold promoted the adhesion, spreading, proliferation and function of cardiomyoblast H9C2 cells in a manner comparable to that for the poly(lactic-co-glycolic acid) scaffold. It exhibited an excellent water-responsive shape memory effect with a fixity and recovery ratio >97% and a shape-recovery process of several minutes, suitable for surgery. In addition, the PFOT scaffold presented good in vitro biodegradation. More importantly, PFOT contains extensive free hydroxyl ...
- Subjects :
- Scaffold
Materials science
0206 medical engineering
Biomedical Engineering
One-Step
02 engineering and technology
Shape-memory alloy
Adhesion
Biodegradation
021001 nanoscience & nanotechnology
020601 biomedical engineering
Copolyester
Biomaterials
Shape-memory polymer
Chemical engineering
Polymerization
0210 nano-technology
Subjects
Details
- ISSN :
- 23739878
- Volume :
- 5
- Database :
- OpenAIRE
- Journal :
- ACS Biomaterials Science & Engineering
- Accession number :
- edsair.doi...........f002650cb8b9636c15e2510464755c39