Thermodynamic properties of resveratrol in dimethyl sulfoxide

In this article, the enthalpies of dissolution of resveratrol in dimethyl sulfoxide (DMSO) were measured using a RD496-2000 Calvet microcalorimeter at 298.15 K under atmospheric pressure. The differential enthalpy (Δdif H m) and molar enthalpy (Δsol H m) of dissolution of resveratrol in DMSO were determined, and the relationship between heat and the amount of solute was also established. Based on the thermodynamic and kinetic knowledge, the corresponding kinetic equation, half-life, Δsol H m, Δsol S m, Δsol G m, the relative partial molar enthalpy (Δsol H m(partial)) and the relative apparent molar enthalpy (Δsol H m(app)) of the dissolution process were obtained. The results showed that this study not only provided a simple method for the determination of the half-life for a drug, but also offered a theoretical reference for the clinical application of resveratrol.