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Joining of VK to JK gene segments in a retroviral vector introduced into lymphoid cells

Authors :
Ann M. Gifford
David Baltimore
Susanna M. Lewis
Source :
Nature. 308:425-428
Publication Year :
1984
Publisher :
Springer Science and Business Media LLC, 1984.

Abstract

VK to JK recombination occurred within a DNA construct introduced into cells in the form of a defective retrovirus. Analysis of one recombinant demonstrated that VK–JK joining can occur via inversion with a net loss of a few base pairs.

Details

ISSN :
14764687 and 00280836
Volume :
308
Database :
OpenAIRE
Journal :
Nature
Accession number :
edsair.doi...........f12cb38a2510fa5c9558e1abd40fcb3e
Full Text :
https://doi.org/10.1038/308425a0