ChemInform Abstract: Homoallylic Alcohols and Trichloroacetamides as Hydrogen Bond Donors for Directed Dihydroxylation

Authors :: Madeleine Helliwell
Andrew Simon Bell
Timothy J. Donohoe
Nicholas John Newcombe
Lee Mitchell
Michael J. Waring
Source :: ChemInform. 33
Publication Year :: 2010
Publisher :: Wiley, 2010.
Abstract: The synthesis and directed dihydroxylation of a series of homoallylic alcohols and trichloroacetamides is described. Using the combination of OsO 4 and TMEDA, moderate to high levels of stereoselectivity were obtained, depending upon the structure of the substrate. Proof of the structure of two osmate esters was obtained through X-ray crystallography.

Subjects :: Hydroxylation
chemistry.chemical_compound
chemistry
Hydrogen bond
Dihydroxylation
Organic chemistry
Substrate (chemistry)
Stereoselectivity
General Medicine

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