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Proliferation Effects on Hair Growth of Compounds Isolated from the Bark of Dalbergia oliveri

Authors :
Jong Hyuk Sung
Seung Hyun Kim
Guijae Yoo
Bui Huu Tai
Phan Van Kiem
Seok Hyun Oh
Hoang Le Tuan Anh
Pham Thanh Loan
Nanyoung Kim
Nguyen Xuan Nhiem
Hee Jae Kwak
Seon Ju Park
Jun Hyung Park
Source :
Natural Product Communications. 12:1934578X1701201
Publication Year :
2017
Publisher :
SAGE Publications, 2017.

Abstract

One new isoflavane, 7,4′-dihydroxy-isoflavanquinone (1), together with ten known compounds (2–11) were isolated from the bark of Dalbergia oliveri Prain. The structures of compounds were determined on the basis of extensive spectroscopic methods, including 1D and 2D NMR and CD spectroscopic data. Using a cell proliferation assay, the isolated compounds were evaluated for their proliferation effects on hair growth. (3 R)-5’-Methoxyvestitol (2) and (6a R,11a R)-3,8-dihydroxy-9-methoxypterocarpan (10) significantly increased the proliferation of immortalized dermal papilla cells (iDPC).

Details

ISSN :
15559475 and 1934578X
Volume :
12
Database :
OpenAIRE
Journal :
Natural Product Communications
Accession number :
edsair.doi...........f1ddf43ca0730eb0ebab413d80dac433
Full Text :
https://doi.org/10.1177/1934578x1701201117