ChemInform Abstract: Total Syntheses of CP-225,917 and CP-263,114: Creation of a Matrix Structure by Sequential Aldol Condensation and Intramolecular Heck Ring Closure

Authors :: Dongfang Meng
Derin C. D'Amico
Ohyun Kwon
Wei Deng
Dai-Shi Su
Samuel J. Danishefsky
Source :: ChemInform. 29
Publication Year :: 2010
Publisher :: Wiley, 2010.
Abstract: Important progress towards the total syntheses of the title compounds, potent inhibitors of squalene synthase and farnesyl transferase, has been accomplished by the construction of the highly functionalized compound 1.

Subjects :: Matrix (chemical analysis)
Squalene
chemistry.chemical_compound
Chemistry
Stereochemistry
organic chemicals
Intramolecular force
lipids (amino acids, peptides, and proteins)
Farnesyl Transferase
Aldol condensation
General Medicine
Ring (chemistry)
environment and public health

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