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Synthesis, Characterization and Application of Some Axially Chiral Binaphthyl Phosphoric Acids in Asymmetric Mannich Reaction
- Source :
- Chinese Journal of Chemistry. 33:601-609
- Publication Year :
- 2015
- Publisher :
- Wiley, 2015.
-
Abstract
- Two novel chiral Br?nsted acids 3b and 3c were prepared without involving the complexity of Suzuki coupling. Catalyst 3c bearing two additional hydroxyl groups at 3 and 3′ positions of axially chiral 1,1-binaphthalene-2,2′-diol phosphoric acid was applied in a model Mannich reaction to afford β-amino ester in high yield (92%) and enantiomeric excess (91%) at low reacting temperature of −40°C. In addition, those β-amino ester derivatives with high yields and excellent enatioselectivities were obtained in the presence of catalyst 3c under the above condition.
Details
- ISSN :
- 1001604X
- Volume :
- 33
- Database :
- OpenAIRE
- Journal :
- Chinese Journal of Chemistry
- Accession number :
- edsair.doi...........f3364bfa35e116d56ab355db1d2275d6