Back to Search
Start Over
Ruthenium-catalysed synthesis of chiral exocyclic allylic alcohols via chemoselective transfer hydrogenation of 2-arylidene cycloalkanones
- Source :
- Green Chemistry. 23:1628-1632
- Publication Year :
- 2021
- Publisher :
- Royal Society of Chemistry (RSC), 2021.
-
Abstract
- An exclusive asymmetric reduction of CO bonds of 2-arylidene four-, five-, six-, and seven-membered cycloalkanones has been studied systematically. The asymmetric transfer hydrogenation was performed using a robust and commercially available chiral diamine-derived ruthenium complex as a catalyst and HCOOH/Et3N as a hydrogen source under mild conditions, giving 51 examples of chiral exocyclic allylic alcohols in up to 96% yield and 99% ee. This method was also applicable to the gram-scale synthesis of the active intermediates of the anti-inflammatory loxoprofen and natural product (−)-goniomitine.
Details
- ISSN :
- 14639270 and 14639262
- Volume :
- 23
- Database :
- OpenAIRE
- Journal :
- Green Chemistry
- Accession number :
- edsair.doi...........f3453b295aa5f003f5266e5b291f4a6e