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Calbindin expression in adult vestibular epithelia
- Source :
- Journal of Comparative Physiology A. 206:623-637
- Publication Year :
- 2020
- Publisher :
- Springer Science and Business Media LLC, 2020.
-
Abstract
- The mammalian vestibular epithelia exhibit a remarkably stereotyped organization featuring cellular characteristics under planar cell polarity (PCP) control. PCP mechanisms are responsible for the organization of hair cell morphologic polarization vectors, and are thought to be responsible for the postsynaptic expression of the calcium-binding protein calretinin that defines the utricular striola and cristae central zone. However, recent analyses revealed that subtle differences in the topographic expression of oncomodulin, another calcium-binding protein, reflects heterogeneous factors driving the subtle variations in expression. Calbindin represents a third calcium-binding protein that has been previously described to be expressed in both hair cells and afferent calyces in proximity to the utricular striola and crista central zone. The objective of the present investigation was to determine calbindin’s topographic pattern of expression to further elucidate the extent to which PCP mechanisms might exert control over the organization of vestibular neuroepithelia. The findings revealed that calbindin exhibited an expression pattern strikingly similar to oncomodulin. However, within calyces of the central zone calbindin was colocalized with calretinin. These results indicate that organizational features of vestibular epithelia are governed by a suite of factors that include PCP mechanisms as well others yet to be defined.
- Subjects :
- Vestibular system
0303 health sciences
Oncomodulin
biology
Physiology
030310 physiology
Calbindin
Cell biology
03 medical and health sciences
Behavioral Neuroscience
Crista
0302 clinical medicine
medicine.anatomical_structure
Postsynaptic potential
Utricle
biology.protein
medicine
Animal Science and Zoology
Hair cell
Calretinin
030217 neurology & neurosurgery
Ecology, Evolution, Behavior and Systematics
Subjects
Details
- ISSN :
- 14321351 and 03407594
- Volume :
- 206
- Database :
- OpenAIRE
- Journal :
- Journal of Comparative Physiology A
- Accession number :
- edsair.doi...........f4606cfd966043af5dd77e54de5951cf