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Quercetin attenuates hypertension induced by sodium fluoride via reduction in oxidative stress and modulation of HSP 70/ERK/PPARĪ³ signaling pathways
- Source :
- BioFactors. 44:465-479
- Publication Year :
- 2018
- Publisher :
- Wiley, 2018.
-
Abstract
- Hypertension is one of the silent killers in the world with high mortality and morbidity. The exposure of humans and animals to fluoride and/or fluoride containing compounds is almost inevitable. This study investigated the modulatory effects of quercetin on sodium fluoride (NaF)-induced hypertension and cardiovascular complications. Forty male rats were randomly separated into four groups (n =10). Group A animals served as the control, rats in Group B were exposed to 300 ppm of NaF, Groups C and D animals were exposed to 300 ppm of NaF along with quercetin orally at 50 mg/kg and 100 mg/kg orally by gavage, while NaF was administered in drinking water, respectively, for a week. Administration of NaF caused severe hypertension as indicated with significant increases in the systolic, diastolic, and mean arterial blood pressure, together with prolonged ventricular depolarization (QRS) and the time between the start of the Q wave and the end of the T wave in the heart's electrical cycle (QT) intervals when compared with controls. NaF significantly decreased the activities of antioxidant enzymes, caused increase in markers of oxidative stress and renal damage when compared with controls. Immunohistochemical staining revealed lower expressions of Hsp70, ERK, and PPARĪ³ in the heart, kidney, and aorta of rats-administered NaF relative to the controls. Together, quercetin co-treatment with NaF restored blood pressure, normalized QRS interval, and improved antioxidant defense system. © 2018 BioFactors, 44(5):465-479, 2018.
- Subjects :
- 0301 basic medicine
medicine.medical_specialty
Antioxidant
medicine.medical_treatment
Clinical Biochemistry
Diastole
medicine.disease_cause
Biochemistry
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Internal medicine
Sodium fluoride
medicine
Kidney
General Medicine
body regions
030104 developmental biology
Endocrinology
medicine.anatomical_structure
Blood pressure
chemistry
030220 oncology & carcinogenesis
Molecular Medicine
Quercetin
Fluoride
Oxidative stress
Subjects
Details
- ISSN :
- 09516433
- Volume :
- 44
- Database :
- OpenAIRE
- Journal :
- BioFactors
- Accession number :
- edsair.doi...........f4d6078ecfda77ea68b8aeb1b32118ff
- Full Text :
- https://doi.org/10.1002/biof.1445