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Health-related quality of life and burden of fatigue in patients with primary immune thrombocytopenia by phase of disease
- Source :
- American Journal of Hematology. 91:995-1001
- Publication Year :
- 2016
- Publisher :
- Wiley, 2016.
-
Abstract
- The main objective of this study was to compare health-related quality of life (HRQOL) of primary immune thrombocytopenia (pITP) patients with that of general population, overall, and by patient group (i.e., newly diagnosed, persistent, and chronic patients). Fatigue was also investigated as a secondary objective. Overall, 424 adult patients were enrolled in a multicenter observational study and the control group consisted of a representative sample from the general population. Propensity score matching plus further multivariate linear regression adjustment was used to compare HRQOL outcomes between pITP patients and general population. Mean age of patients was 54 years. Of those with HRQOL assessment, 99 patients (23.6%) were newly diagnosed, 53 (12.6%) were persistent, and 268 (63.8%) were chronic pITP patients. Comparison by patient group versus their respective peers in the general population revealed greater impairments in persistent pITP patients. Persistent pITP patients reported clinically meaningful impairments in physical functioning (-15; 95% CI -24.1 to -5.8; P = 0.002), social functioning (-15.3; 95% CI -25.5 to -5.1; P = 0.004), role physical (-28.4; 95% CI -43.1 to -13.7; P
- Subjects :
- medicine.medical_specialty
education.field_of_study
business.industry
Population
Physical fitness
Hematology
Disease
03 medical and health sciences
0302 clinical medicine
Quality of life
030220 oncology & carcinogenesis
Internal medicine
Bayesian multivariate linear regression
Propensity score matching
Immunology
Severity of illness
Medicine
Observational study
business
education
030215 immunology
Subjects
Details
- ISSN :
- 03618609
- Volume :
- 91
- Database :
- OpenAIRE
- Journal :
- American Journal of Hematology
- Accession number :
- edsair.doi...........f5a20907c6bc251616e8f3be8e9afcad