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Catecholamine-Containing Biodegradable Microsphere Implants: An Overview of Experimental Studies in Dopamine-Lesioned Rats
- Source :
- Alzheimer’s and Parkinson’s Diseases ISBN: 9781475791471
- Publication Year :
- 1995
- Publisher :
- Springer US, 1995.
-
Abstract
- The main neurochemical characteristic of Parkinson’s disease (PD) is a marked lesion of the nigro-striatal dopamine pathway. In attempts to provide dopamine replacement therapy to Parkinson’s patients, the current medication is L-DOPA (Birkmayer and Hornykiewicz, 1961). Dopamine (DA) itself cannot be taken orally because it will not reach the brain. Unfortunately, L-DOPA can cause serious adverse reactions and its effectiveness decreases with time. For these reasons, there has been an increasing demand for and interest in novel techniques for site-directed delivery of substances into the central nervous system (CNS) (Stahl, 1984).
Details
- ISBN :
- 978-1-4757-9147-1
- ISBNs :
- 9781475791471
- Database :
- OpenAIRE
- Journal :
- Alzheimer’s and Parkinson’s Diseases ISBN: 9781475791471
- Accession number :
- edsair.doi...........f6e5d767798b6069754a1df40a3e7a73