Synthesis of symmetric dicyclohexanocucurbit[6]uril and its interaction with glycine

In this study, cyclohexanol was used as the raw material to replace cyclohexanone during the synthesis of symmetric dicyclohexanocucurbit[6]uril (CyH2Q[6]), which successfully avoided the use of selenium dioxide and greatly improved the yield of cyclohexyl-substituted glycoluril as the intermediate product (96%). In addition, using CyH2Q[6] as the host molecule and glycine (Gly) as the guest, the interaction mode between the two in both an aqueous and solid phase was studied using 1H NMR spectroscopy and X-ray crystallography. Analysis of the 1H NMR spectra and crystal structure showed that CyH2Q[6] and Gly form a 1:2 host–guest inclusion compound.