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Immunohistochemical analysis of cyclooxygenase-2 and brain fatty acid binding protein expression in grades I-II meningiomas: Correlation with tumor grade and clinical outcome after radiotherapy

Authors :
Hyun-Cheol Kang
Charn Il Park
Il Han Kim
Sung Hye Park
Source :
Neuropathology. 34:446-454
Publication Year :
2014
Publisher :
Wiley, 2014.

Abstract

This study was done to evaluate the association of cyclooxygenase 2 (COX-2) and brain fatty acid binding protein (BFABP) with tumor grade and outcome of grades I-II meningiomas treated with radiotherapy. From 1996 to 2008, 40 patients with intracranial grades I-II meningiomas were treated with radiotherapy. Immunohistochemical staining for COX-2 and BFABP were performed on formalin-fixed paraffin-embedded tissues. COX-2 expression was significantly associated with BFABP status and both COX-2 (P < 0.01) and BFABP (P = 0.01) expression were stronger in the grade II meningiomas than in grade I tumors. Among the clinicopathologic factors, age and COX-2 status were prognostic in progression-free survival. Patients with moderate or strong COX-2 expression had worse outcome than those with negative or weak COX-2 expression (P = 0.03) after controlling for potential confounders. Our results suggest that the molecular biomarker COX-2 has prognostic significance in intracranial grades I-II meningiomas following radiotherapy.

Details

ISSN :
09196544
Volume :
34
Database :
OpenAIRE
Journal :
Neuropathology
Accession number :
edsair.doi...........f70a27f95f71f2dd3df4911de0e65337
Full Text :
https://doi.org/10.1111/neup.12128