SIX CARCINOMAS WERE SYNCHRONOUSLY REVEALED IN THE COLON-REPORT OF A CASE

We report a rare case of synchronous multiple carcinomas of the colon. A 65-year-old man visited our hospital because of anal bleeding. Colonoscopy disclosed an ulcerative lesion in the sigmoid colon and 10 polypoid lesions in the ascending and sigmoid colon. After endoscopic polypectomy of the 10 polypoid lesions, anterior resection with lymph node dissection was performed for the ulcerative lesion. Histological study revealed one advanced carcinoma with invasion of the subserosa, 5 early carcinomas with invasion of the mucosa or submosa, and 3 adenomas with moderate to severe atypia. The genetic instability of these 9 lesions was examined using microsatellite assay. In all of these lesions, no replication errors were detected at any of the microsatellite loci analyzed.