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Soluble MICB in Plasma and Urine Explains Population Expansions of NKG2D+CD4 T Cells Inpatients with Juvenile-Onset Systemic Lupus Erythematosus

Authors :
Anne M. Stevens
Kate L. Duran
Veronika Groh
Andrea Caballero-Benitez
Thomas A. Spies
Satoru Hamada
Source :
Open Journal of Immunology. :1-17
Publication Year :
2017
Publisher :
Scientific Research Publishing, Inc., 2017.

Abstract

Abnormal NKG2D ligand expression has been implicated in the initiation and maintenance of various auto-inflammatory disorders including systemic lupus erythematosus (SLE). This study’s goal was to identify the cellular contexts providing NKG2D ligands for stimulation of the immunosuppressive NKG2D+CD4 T cell subset that has been implicated in modulating juvenile-onset SLE disease activity. Although previous observations with NKG2D+CD4 T cells in healthy individuals pointed towards peripheral B cell and myeloid cell compartments as possible sites of enhanced NKG2DL presence, we found no evidence for a disease-associated increase of NKG2DL-positivity among juvenile-onset SLE B cells and monocytes. However, juvenile-onset SLE patient plasma and matched urine samples were positive by ELISA for the soluble form of the NKG2D ligands MICA and MICB, suggesting that kidney and/or peripheral blood may constitute the NKG2DL positive microenvironments driving NKG2D+CD4 T cell population expansions in this disease.

Details

ISSN :
21624526 and 2162450X
Database :
OpenAIRE
Journal :
Open Journal of Immunology
Accession number :
edsair.doi...........f75a3c52a95128e270ce5f7bf809782f
Full Text :
https://doi.org/10.4236/oji.2017.71001