ChemInform Abstract: Stereoselective Approach to 2,6-Disubstituted Piperidin-3-ol: Synthesis of (-)-Deoxoprosopinine and (+)-Deoxoprosophylline

A simple and highly efficient approach to an enantioenriched 2,6-disubstituted piperidin-3-ol skeleton is developed from an aldehyde as a starting material by using organocatalytic and asymmetric dihydroxylation as the key steps. Its application to the total synthesis of (–)-deoxoprosopinine and (+)-deoxoprosophylline is also reported.