Back to Search
Start Over
Donor Age and Corneal Endothelial Cell Loss 5 Years after Successful Corneal Transplantation
- Source :
- Ophthalmology. 115:627-632.e8
- Publication Year :
- 2008
- Publisher :
- Elsevier BV, 2008.
-
Abstract
- Objective To determine whether endothelial cell loss 5 years after successful corneal transplantation is related to the age of the donor. Design Multicenter, prospective, double-masked clinical trial. Participants Three hundred forty-seven subjects participating in the Cornea Donor Study who had not experienced graft failure 5 years after corneal transplantation for a moderate-risk condition (principally Fuchs' dystrophy or pseudophakic corneal edema). Testing Specular microscopic images of donor corneas obtained before surgery and postoperatively at 6 months, 12 months, and then annually through 5 years were submitted to a central reading center to measure endothelial cell density (ECD). Main outcome measure Endothelial cell density at 5 years. Results At 5 years, there was a substantial decrease in ECD from baseline for all donor ages. Subjects who received a cornea from a donor 12 to 65 years old experienced a median cell loss of 69% in the study eye, resulting in a 5-year median ECD of 824 cells/mm(2) (interquartile range, 613-1342), whereas subjects who received a cornea from a donor 66 to 75 years old experienced a cell loss of 75%, resulting in a median 5-year ECD of 654 cells/mm(2) (interquartile range, 538-986) (P [adjusted for baseline ECD] = 0.04). Statistically, there was a weak negative association between ECD and donor age analyzed as a continuous variable (r [adjusted for baseline ECD] = -0.19; 95% confidence interval, -0.29 to -0.08). Conclusions Endothelial cell loss is substantial in the 5 years after corneal transplantation. There is a slight association between cell loss and donor age. This finding emphasizes the importance of longer-term follow-up of this cohort to determine if this relationship affects graft survival.
- Subjects :
- medicine.medical_specialty
genetic structures
Endothelium
business.industry
Fuchs Endothelial Dystrophy
medicine.medical_treatment
Confidence interval
Surgery
Ophthalmology
medicine.anatomical_structure
Interquartile range
Cornea
Cohort
medicine
business
Prospective cohort study
Corneal transplantation
Subjects
Details
- ISSN :
- 01616420
- Volume :
- 115
- Database :
- OpenAIRE
- Journal :
- Ophthalmology
- Accession number :
- edsair.doi...........f9e80d47fa37b2c65ce4c54ad972c7b9